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Saturday, March 19, 2011

Psychology: Not All Sedative Is Same

Confusion about what is called a sedative to make me a bit much review about it this time. In practice as a psychiatrist Psychosomatic, I see more cases of psychosomatic complaints which is basically the anxiety disorders and depressive disorders. Both types of diagnosis is the most widely psychosomatic complaints with the conditions as the top cause of panic disorder (Data in Psychosomatic Clinic Hospital OMNI in 2009, more than 80% of patients with psychosomatic complaints is essentially a diagnosis of Panic Disorder).

Current treatment for anxiety disorders include panic disorder is to use an SSRI class of antidepressants (selective serotonin reuptake inhibitors). The use of drugs benzodiazepines anxiety group (which is often misconstrued as a sedative) is only used when initial treatment (if necessary) and used in a short time frame.


Below I will discuss about it with a simple language (non-textbook words) so easily understood by the reader as well.

Know Antidepressants and Antianxietas (anticemas)

Antidepressants

How it works by giving effect on monoamine systems, serotonin and norepinephrine. However, not all antidepressants have the effect of the third brain system.
Some examples of antidepressant drugs:

Tricyclic class

The most famous is AMITRYPTILINE 25 mg, an antidepressant that is cheap (the price is only 200-600 setablet silver) is available in generic form. Still used primarily for patients in the clinic, have a good antinyeri effect so often a concoction of drugs to the doctors nervous. Unfortunately cause drowsiness effect remarkable even though the recommended 3 times a day but usually only eaten at night only. Effects to the Heart of the less well lead to the use of these drugs is limited to young adults and almost never given to the elderly who suffer from heart disorders.

Group Tertrasiklik

Similar to the above category, brand tekenal is LUDIOMIL with Maproptiline generic brand (not available)

Monoamine Group

Known for its trademark AURORIX MOCLOBLEMIDE generic contents. Drugs including old and rarely used anymore because of side effects that endanger the serotonin poisoning. This drug in some cold medicines should not be given. So if a patient asked me if that antidepressants can eat meal of cold medicine, the answer may be just do not eat this drug.

Serotonin Group
Is the latest group of the most recommended at this time because of good tolerance and minimal side effects. Several types and famous trademarks are:
Fluoxetine (Kalxetin, Prozac, Antiprestin, Lodep)
Sertraline (Serlof, Zoloft, Antipres)
Escitalopram (Cipralex)
Paroxetine (Seroxat) -> has been rarely used in Indonesia

The most frequent side effect is nausea and stomach upsets, but usually with a small initial dose and increased slowly this can be neutralized

Serotonin-Norepinephrine Group

It is the most recent class, the famous brand is Cymbalta and Effexor. It is not available in Indonesia for some time.
Side effects similar to serotonin, but sometimes high blood pressure like it was found after usage.

Benzodiazepine

Known to the public as a sedative, apparently macam2 and most famous is the contents of alprazolam xanax.

Another class is

a. Alprazolam (xanax, calmlet, zypraz et al)
ggn intended for patients to panic and not the other. but krn effects of physiological and psychological dependence eminence, since some of this year recommended sdah not be given if the patient does not need to once and can still be handled by other classes of drugs such as clobazam (frisium). Moreover, first-line therapy for patients with panic is Antidepressants

b. Clobazam (Frisium)
The drug is not known in the USA. More widely prescribed in Japan and Europe. Safe enough, but the effect is not as advanced alprazolam. Ngantuknya effects were minimal and it works quite a long time. Ordinary given only at the beginning of therapy.

c. Estazolam (Esilgan)
Known as sleeping pills, commonly prescribed in the form of dosage of 1 mg and 2 mg
Should not be used in conjunction with other anticemas drug. High sedation so classified into sedative hypnotics. For sleep disturbance was yahud but better use of the lighter classes first.
Hang over is often experienced by users of these drugs, poisoning resulting from the use of many causes of prolonged sedation even if it has been rinsed off the hull and had used drugs out of urine.

d. Lorazepam (Ativan)
Safe for the elderly, because due to metabolites or remnant metabolism in the blood no longer active, wktu short work that is safe for the elderly and impaired renal pasien2.
The dose varied from 0.5 mg to 2 mg 1mg

e.Diazepam (Valium, valisanbe)
Drug anticemas classical, least expensive and much use of small children (babies) are used as a drug that is inserted into the rectum in the form of suppositories (stesolid) for febrile seizures until the concoction for patients with pain. The effect is in addition to sedative muscle relaxant as well. Long working time so that often hangs over ... Not recommended for the elderly

Hopefully help

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